In vivo dopamine transporter imaging in a unilateral 6-hydroxydopamine rat model of Parkinson disease using 11C-methylphenidate PET.
Identifieur interne : 001210 ( Main/Exploration ); précédent : 001209; suivant : 001211In vivo dopamine transporter imaging in a unilateral 6-hydroxydopamine rat model of Parkinson disease using 11C-methylphenidate PET.
Auteurs : Vesna Sossi [Canada] ; Katherine Dinelle ; Salma Jivan ; Kristina Fischer ; James E. Holden ; Doris DoudetSource :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine [ 1535-5667 ] ; 2012.
English descriptors
- KwdEn :
- Animals, Carbon Radioisotopes, Disease Models, Animal, Dopamine Plasma Membrane Transport Proteins (metabolism), Image Processing, Computer-Assisted, Male, Methylphenidate, Oxidopamine, Parkinson Disease (diagnostic imaging), Parkinson Disease (metabolism), Positron-Emission Tomography, Rats, Rats, Sprague-Dawley.
- MESH :
- chemical , metabolism : Dopamine Plasma Membrane Transport Proteins.
- chemical : Carbon Radioisotopes, Methylphenidate, Oxidopamine.
- diagnostic imaging : Parkinson Disease.
- metabolism : Parkinson Disease.
- Animals, Disease Models, Animal, Image Processing, Computer-Assisted, Male, Positron-Emission Tomography, Rats, Rats, Sprague-Dawley.
Abstract
Dopamine transporter (DAT) function is altered by many neurodegenerative diseases. For instance, in Parkinson disease DAT density has been shown to decrease in early disease and to play a role in the occurrence of motor complications. DAT is thus an important imaging target with potential therapeutic relevance in humans and animal models of disease. The PET DAT marker (11)C-methylphenidate is commonly used to quantify DAT function. Here we investigate the characteristics of the (11)C-methylphenidate-derived quantification of DAT in rodents using the 6-hydroxydopamine Parkinson disease rat model.
DOI: 10.2967/jnumed.111.101436
PubMed: 22492730
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000A73
- to stream PubMed, to step Curation: 000A73
- to stream PubMed, to step Checkpoint: 000A73
- to stream Ncbi, to step Merge: 001115
- to stream Ncbi, to step Curation: 001115
- to stream Ncbi, to step Checkpoint: 001115
- to stream Main, to step Merge: 001235
- to stream Main, to step Curation: 001210
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">In vivo dopamine transporter imaging in a unilateral 6-hydroxydopamine rat model of Parkinson disease using 11C-methylphenidate PET.</title><author><name sortKey="Sossi, Vesna" sort="Sossi, Vesna" uniqKey="Sossi V" first="Vesna" last="Sossi">Vesna Sossi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada. vesna@physics.ubc.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Dinelle, Katherine" sort="Dinelle, Katherine" uniqKey="Dinelle K" first="Katherine" last="Dinelle">Katherine Dinelle</name></author><author><name sortKey="Jivan, Salma" sort="Jivan, Salma" uniqKey="Jivan S" first="Salma" last="Jivan">Salma Jivan</name></author><author><name sortKey="Fischer, Kristina" sort="Fischer, Kristina" uniqKey="Fischer K" first="Kristina" last="Fischer">Kristina Fischer</name></author><author><name sortKey="Holden, James E" sort="Holden, James E" uniqKey="Holden J" first="James E" last="Holden">James E. Holden</name></author><author><name sortKey="Doudet, Doris" sort="Doudet, Doris" uniqKey="Doudet D" first="Doris" last="Doudet">Doris Doudet</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22492730</idno><idno type="pmid">22492730</idno><idno type="doi">10.2967/jnumed.111.101436</idno><idno type="wicri:Area/PubMed/Corpus">000A73</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A73</idno><idno type="wicri:Area/PubMed/Curation">000A73</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A73</idno><idno type="wicri:Area/PubMed/Checkpoint">000A73</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000A73</idno><idno type="wicri:Area/Ncbi/Merge">001115</idno><idno type="wicri:Area/Ncbi/Curation">001115</idno><idno type="wicri:Area/Ncbi/Checkpoint">001115</idno><idno type="wicri:Area/Main/Merge">001235</idno><idno type="wicri:Area/Main/Curation">001210</idno><idno type="wicri:Area/Main/Exploration">001210</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">In vivo dopamine transporter imaging in a unilateral 6-hydroxydopamine rat model of Parkinson disease using 11C-methylphenidate PET.</title><author><name sortKey="Sossi, Vesna" sort="Sossi, Vesna" uniqKey="Sossi V" first="Vesna" last="Sossi">Vesna Sossi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada. vesna@physics.ubc.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Dinelle, Katherine" sort="Dinelle, Katherine" uniqKey="Dinelle K" first="Katherine" last="Dinelle">Katherine Dinelle</name></author><author><name sortKey="Jivan, Salma" sort="Jivan, Salma" uniqKey="Jivan S" first="Salma" last="Jivan">Salma Jivan</name></author><author><name sortKey="Fischer, Kristina" sort="Fischer, Kristina" uniqKey="Fischer K" first="Kristina" last="Fischer">Kristina Fischer</name></author><author><name sortKey="Holden, James E" sort="Holden, James E" uniqKey="Holden J" first="James E" last="Holden">James E. Holden</name></author><author><name sortKey="Doudet, Doris" sort="Doudet, Doris" uniqKey="Doudet D" first="Doris" last="Doudet">Doris Doudet</name></author></analytic><series><title level="j">Journal of nuclear medicine : official publication, Society of Nuclear Medicine</title><idno type="eISSN">1535-5667</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Carbon Radioisotopes</term><term>Disease Models, Animal</term><term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term><term>Image Processing, Computer-Assisted</term><term>Male</term><term>Methylphenidate</term><term>Oxidopamine</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (metabolism)</term><term>Positron-Emission Tomography</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Carbon Radioisotopes</term><term>Methylphenidate</term><term>Oxidopamine</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Image Processing, Computer-Assisted</term><term>Male</term><term>Positron-Emission Tomography</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dopamine transporter (DAT) function is altered by many neurodegenerative diseases. For instance, in Parkinson disease DAT density has been shown to decrease in early disease and to play a role in the occurrence of motor complications. DAT is thus an important imaging target with potential therapeutic relevance in humans and animal models of disease. The PET DAT marker (11)C-methylphenidate is commonly used to quantify DAT function. Here we investigate the characteristics of the (11)C-methylphenidate-derived quantification of DAT in rodents using the 6-hydroxydopamine Parkinson disease rat model.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Dinelle, Katherine" sort="Dinelle, Katherine" uniqKey="Dinelle K" first="Katherine" last="Dinelle">Katherine Dinelle</name><name sortKey="Doudet, Doris" sort="Doudet, Doris" uniqKey="Doudet D" first="Doris" last="Doudet">Doris Doudet</name><name sortKey="Fischer, Kristina" sort="Fischer, Kristina" uniqKey="Fischer K" first="Kristina" last="Fischer">Kristina Fischer</name><name sortKey="Holden, James E" sort="Holden, James E" uniqKey="Holden J" first="James E" last="Holden">James E. Holden</name><name sortKey="Jivan, Salma" sort="Jivan, Salma" uniqKey="Jivan S" first="Salma" last="Jivan">Salma Jivan</name></noCountry><country name="Canada"><noRegion><name sortKey="Sossi, Vesna" sort="Sossi, Vesna" uniqKey="Sossi V" first="Vesna" last="Sossi">Vesna Sossi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001210 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001210 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:22492730
|texte= In vivo dopamine transporter imaging in a unilateral 6-hydroxydopamine rat model of Parkinson disease using 11C-methylphenidate PET.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22492730" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |